Phenacyl bromide → HCID 13476634, compound

Participants

Reaction Steps

250 g of 2-acetamido-3-cyano-4-methyl-5-ethoxycarbonylthiophene, prepared in accordance with the method of K. Gewald, are refluxed for 24 hours in 1500 ml of acetone with 250 g of α-bromoacetophenone and 220 g of potassium carbonate; the whole is then precipitated in 4000 ml of ice-water. The resulting precipitate is filtered, washed with 1000 ml of an iced mixture of water/ethanol (1/1), then dried and finally washed with 1000 ml of a cold mixture of cyclohexane/benzene (9/1). In this manner 295 g of 2-ethoxycarbonyl-3-methyl-4-amino-5-benzoyl-6-acetylthieno[2,3-b]pyrrole are obtained, m.p.: 188° C.

Provenance & Evidence