Bromine → 1-(Bromomethyl)-2-chloro-4-fluorobenzene

A solution of bromine (7.10 ml) in carbon tetrachloride (70 ml) was added slowly over a period of 3 hours to a solution of 2-chloro-4-fluorotoluene (20.0 g) in carbon tetrachloride (80 ml) maintained at the reflux temperature and irradiated by light from a tungsten lamp (200 watt). After the addition was completed the mixture was heated at the reflux temperature with irradiation until the colour had been discharged (ca.1 hour). The solvent was then removed by evaporation under reduced pressure and the residual oil distilled to yield 2-chloro-4-fluorobenzyl bromide (80% pure, 18.0 g) b.p. 110°-120° C./15 mm Hg.

1. temperaturemaintained at the reflux temperature
2. customirradiated by light from a tungsten lamp (200 watt)
3. additionAfter the addition
4. temperaturewas heated at the reflux temperature with irradiation until the colour
5. custom(ca.1 hour)
6. customThe solvent was then removed by evaporation under reduced pressure
7. distillationthe residual oil distilled

ORD record

ord-204de32b0a5f46b4934b5b813810a3cf

Source dataset

uspto-grants-1986_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04567199