Water → HCID 13338866, compound

Participants

Reaction Steps

A mixture of 1-(4-acetyl-3-hydroxy-2-n-propylphenoxy)-3-(2-chloro-4-cyanophenoxy)propane (1 g), potassium hydroxide (2 g), water (5 ml) and ethanol (10 ml) was refluxed for 4 hours, then concentrated, acidified with dilute hydrochloric acid and extracted with ethyl acetate. The extract was dried over sodium sulfate, the solvent was distilled off and the residue was recrystallized from ethyl acetate to give 4-[3-(4-acetyl-3-hydroxy-2-n-propylphenoxy)propoxy]-3-chlorobenzoic acid as crystals (780 mg). Melting point 171°-172° C.

Provenance & Evidence