Potassium Chloride → HCID 13120785, compound

HRID 1285420Notes

Reaction equation

HRID 1285420 reaction equation
ClCCC([O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:17])[CH2:11][CH2:10]2)=O.[Cl-:18].[Al+3].[Cl-].[Cl-].[Cl-].[Na+].[Cl-].[K+]>>[OH:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][C:16]=1[C:7](=[O:6])[CH2:16][CH2:15][Cl:18])[NH:13][C:12](=[O:17])[CH2:11][CH2:10]2

Participants

5

Reactant 4

HCID 4873Potassium ChlorideHCID 5234Sodium ChlorideHCID 6451240Aluminum(III) ChlorideHCID 20229417HCID 20229417, compound

Product 1

HCID 13120785HCID 13120785, compound

Procedure

20 Grams of 6-(β-chloropropionyloxy)-3,4-dihydrocarbostyril, 60 g of pulverized anhydrous aluminium chloride, 6 g of sodium chloride and 6 g of potassium chloride were mixed together and the mixture was melted by heating and stirred at 150°-170° C. for 1 hour. The reaction mixture was poured into ice-water and allowed stand overnight to obtain crystalline precipitates. The precipitates were collected by filtration, washed with water and dried, then recrystallized from methanol to obtain 12 g of 6-hydroxy-7-(3-chloropropionyl)-3,4-dihydrocarbostyril in white crystals. Melting point: 205°-208° C.

Workup

  1. temperatureby heating
  2. waitallowed stand overnight
  3. customto obtain crystalline precipitates
  4. filtrationThe precipitates were collected by filtration
  5. washwashed with water
  6. customdried
  7. customrecrystallized from methanol

Sources & evidence

ORD record
ord-617b6e1f3ba149408d817d868a8e8f36
Source dataset
uspto-grants-1986_01
Patent number
US04567187

Reaction notes

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