HCID 20229455, compound → HCID 13120786, compound

HRID 1285422Notes

Reaction equation

HRID 1285422 reaction equation
CS(O[C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[C:16](=[O:20])[CH2:17][CH2:18][Cl:19])[NH:12][C:11](=[O:21])[CH2:10][CH2:9]2)(=O)=O.[H][H]>C(O)C.[Pd]>[Cl:19][CH2:18][CH2:17][C:16]([C:15]1[CH:14]=[C:13]2[C:8]([CH2:9][CH2:10][C:11](=[O:21])[NH:12]2)=[CH:7][CH:6]=1)=[O:20]

Participants

5

Reactant 2

HCID 20229455HCID 20229455, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 13120786HCID 13120786, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

3.0 Grams of 6-methylsulfonyloxy-7-(3-chloropropionyl)-3,4-dihydrocarbostyril and 0.5 g of palladium black were suspended in 200 ml of ethanol and the suspension was subjected to catalytic reduction under 3 atmospheric pressure of hydrogen gas at a room temperature for 5 hours under stirring condition. The reaction mixture was filtered and the mother liquor was concentrated under a reduced pressure to obtain a residue. The residue was recrystallized from ethanol to obtain 1.2 g of 7-(3-chloropropionyl)-3,4-dihydrocarbostyril in colorless powdery-like crystals. Melting point: 159°-161° C.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe mother liquor was concentrated under a reduced pressure
  3. customto obtain a residue
  4. customThe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-692c7b817beb4e11a8283ed6468b672e
Source dataset
uspto-grants-1986_01
Patent number
US04567187

Reaction notes

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