HCID 54434083, compound → HCID 13084716, compound

HRID 1285453Notes

Reaction equation

HRID 1285453 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH:16]=[CH:17][C:18]3[CH:19]=[C:20]4[C:25](=[CH:26][CH:27]=3)[NH:24][C:23](=[O:28])[CH2:22][CH2:21]4)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1>O1CCOCC1.[Pd]>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][CH2:17][C:18]3[CH:19]=[C:20]4[C:25](=[CH:26][CH:27]=3)[NH:24][C:23](=[O:28])[CH2:22][CH2:21]4)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 54434083HCID 54434083, compound

Product 1

HCID 13084716HCID 13084716, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 312751,4-DioxaneSolvent

Procedure

1.0 Gram of 6-{4-[4-(4-Methylphenyl)-1-piperazinyl]-1-butenyl}-3,4-dihydrocarbostyril and 0.2 g of palladium black were suspended in 100 ml of dioxane and the mixture was catalytically hydrogenated under an ordinary pressure at an ordinary temperature. The catalyst was removed by filtration and the filtrate was dried under a reduced pressure. The residue was recrsytallized from isopropanol-diisopropyl ether to obtain 6-{4-[4-(4-methylphenyl)piperazinyl]-butyl}-3,4-dihydrocarbostyril in colorless prism-like crystals. Yield: 0.7 g. Melting point: 160°-161° C.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe filtrate was dried under a reduced pressure

Sources & evidence

ORD record
ord-c1769167bca8419f8f0880f9fbb0288e
Source dataset
uspto-grants-1986_01
Patent number
US04567187

Reaction notes

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