Acetic Acid → HCID 13133064, compound

Participants

Reaction Steps

21.3 g of m-trifluoromethyl-2-formylbenzyl cyanide and 9.7 g of 3(5)-amino-5(3)-methylpyrazole in 100 ml of glacial acetic acid were refluxed for 4 hours. The mixture was cooled and was then diluted with 500 ml of water, the pH was brought to 5-6 with 2N NaOH solution, and the oily product which precipitated crystallized after trituration. The crystals were filtered off under suction and then washed several times with water and dried under reduced pressure at 50° C. 25.0 g of 7-amino-2-methyl-6-(3'-trifluoromethylphenyl)-pyrazolo[1,5-a]pyrimidine of melting point 176° C. were obtained (Compound 10).

Provenance & Evidence