Ammonium Hydroxide → HCID 178422902, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 8.6 g (28 mmole) of N-(2,2-diethoxyethyl)-N'-(2-methylquinolin-5-yl)thiourea and 100 ml of 10% hydrochloric acid was heated on a steam bath for one hour. The solution was allowed to cool to about 20° C., and was then poured with vigorous stirring into a mixture of ice and ammonium hydroxide. The solid was separated by filtration, washed with water, and triturated with ethyl acetate to provide solid 5-(2-mercaptoimidazol-1-yl)-2-methylquinoline.

Provenance & Evidence