Sodium Hydroxide → HCID 23720649, compound

HRID 1285498Notes

Reaction equation

HRID 1285498 reaction equation
[F:1][C:2]1[CH:14]=[C:12]2[C:13]3[N:8]([CH:9]=[C:10]([C:16]([OH:18])=[O:17])[C:11]2=[O:15])[CH:7]([CH3:19])[CH2:6][CH2:5][C:4]=3[C:3]=1[N:20]1[CH:24]=[CH:23][N:22]=[CH:21]1.[OH-].[Na+:26]>O>[OH2:15].[F:1][C:2]1[CH:14]=[C:12]2[C:13]3[N:8]([CH:9]=[C:10]([C:16]([O-:18])=[O:17])[C:11]2=[O:15])[CH:7]([CH3:19])[CH2:6][CH2:5][C:4]=3[C:3]=1[N:20]1[CH:24]=[CH:23][N:22]=[CH:21]1.[Na+:26]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 736409-Fluoro-8-(1H-imidazol-1-yl)-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid

Product 1

HCID 23720649HCID 23720649, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a mixture of 0.500 g (1.53 mmole) of 6,7-dihydro-9-fluoro-8-(imidazol-1-yl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid (from Example 1) and 10 ml of water was added 15.3 ml of 0.1N aqueous sodium hydroxide (1.53 mmole). The mixture was filtered, an equal volume of ethanol added, and the solution evaporated to dryness to give tan crystals of sodium 6,7-dihydro-9-fluoro-8-(imidazol-1-yl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylate hydrate, m.p.>250° C. Analysis: Calculated for C17H13FNaN3O3.1.25H2O: %C, 54.9; %H, 4.2; %N, 11.3; Found: %C, 54.9; %H, 4.4; %N, 10.7.

Workup

  1. filtrationThe mixture was filtered
  2. additionan equal volume of ethanol added
  3. customthe solution evaporated to dryness

Sources & evidence

ORD record
ord-20ffe54410dc495b9a582ef844d93194
Source dataset
uspto-grants-1986_01
Patent number
US04567269

Reaction notes

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