HCID 13338836, compound → HCID 13338838, compound

Participants

Reaction Steps

To a solution of 4.2 g (18 mmole) of 6-fluoro-5-(imidazol-1-yl)-2-methylquinoline in 75 ml of acetic acid was added 0.5 g of platinum on carbon, and the mixture was reduced on a Paar apparatus. After one day the mixture was filtered, the filtrate was evaporated and the residue was diluted with water. The aqueous mixture was basified with 10% aqueous sodium hydroxide solution. The off-white solid was separated by filtration to provide 6-fluoro-5-(imidazol-1-yl)-2-methyl-1,2,3,4-tetrahydroquinoline.

Provenance & Evidence