2-Nitropropane → HCID 13483103, compound

Participants

Reaction Steps

A mixture of 511 mg (2.73 mmoles) of cyanoester 2 (produced in accordance with Example II), 0.25 mL (2.78 mmoles) of 2-nitropropane, and 2.64 mmoles of sodium methoxide (prepared from 61 mg of sodium and methyl alcohol) in 4.0 mL of absolute methanol was stirred at room temperature for 10 minutes and subsequently heated at reflux, protected from atmospheric moisture, for 71/2 hours. The product was isolated as described in the procedure of Example VIII, affording 483 mg (77% yield) of cyclopropanoid cyanoester 11, stereochemically homogeneous as shown by NMR analysis: δ3.83 (singlet, CO2CH3) and δ3.30 (singlet, cyclopropyl H).

Provenance & Evidence