HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitropropane → HCID 13588605, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitropropane | HCID 398 | — |
| Reactant | 4-Methylbenzaldehyde | HCID 7725 | — |
| Reactant | Ethyl cyanoacetate | HCID 7764 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl (2E)-2-cyano-3-(4-methylphenyl)-2-propenoate | HCID 682087 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 13588605 | HCID 13588605 | 74% |
Reaction Steps
A mixture of 576 mg (2.68 mmoles) of (E)-ethyl 2-cyano-3-(p-methylphenyl)-2-propenoate (7) [prepared from ethyl cyanoacetate and p-tolualdehyde (p-methylbenzaldehyde) using the procedure described in Example I for an analogous cyanoester], 0.25 ml (2.78 mmoles) of 2-nitropropane, 398 mg (2.88 mmoles) of anhydrous potassium carbonate, and 2.0 ml of absolute ethanol was heated at reflux for 7 hours. The product was isolated as described in the procedure of Example VIII, affording 511 mg (74% yield) of cyclopropanoid cyanoester 15: bp: 155°-183° C. (bath temperature, 0.15 mm).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04567265 |
| Source dataset | uspto-grants-1986_01 |
| ORD ID | ord-40ad7701beb841989d498e25074bbf07 |
| Source note | uspto-grants-1986_01 |