2-Aminophenol → HCID 13491587, compound

Participants

Reaction Steps

A mixture of 188.6 (1 mole) of 2-chloro-6-methoxy-3-nitropyridine and 262 g (2.4 mole) of o-aminophenol is heated in 500 ml of methanol gradually up to reflux. After heating for a period of 2 hours, the mixture is filtered off hot by suction; the suction cake is washed with enough methanol until the filtrate runs off practically colorless and is dried. Bright red crystals with a melting point of 206°-7° C. are obtained in a yield of 94.6% of theory.

Provenance & Evidence