化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → Darodipine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Ethyl Acetoacetate | HCID 8868 | — |
| 反応物 | 2,1,3-Benzoxadiazole-4-carbaldehyde | HCID 10290873 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Darodipine | HCID 51701 | — |
反応手順
3.2 g of 2,1,3-benzoxadiazole-4-aldehyde, 5.7 g of acetoacetic acid ethyl ester, 2.5 ml of concentrated ammonia and 10 ml of ethanol are refluxed for 6 hours. The mixture is subsequently evaporated and the residual oil is chromatographed on silica gel with chloroform/acetic acid ethyl ester (9:1) to yield the title compound. The product is recrystallised from toluene, m.p. 153°-155°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04567271 |
| 出典データセット | uspto-grants-1986_01 |
| ORD ID | ord-2cf008471cf741f9afe4f566051c8033 |
| 出典メモ | uspto-grants-1986_01 |