HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → Ranolazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | Ranolazine hydrochloride | HCID 71279 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ranolazine | HCID 56959 | 100.3% |
Reaction Steps
A solution of 3.5 g of 1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine dihydrochloride salt in water (50 ml) is adjusted to pH 12 with ammonium hydroxide solution and extracted with methylene chloride. The methylene chloride is evaporated to afford 3 g of 1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine as the free base.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04567264 |
| Source dataset | uspto-grants-1986_01 |
| ORD ID | ord-aab501281038423588943f422f96caf9 |
| Source note | uspto-grants-1986_01 |