2,6-Difluorobenzoyl isocyanate → N-(2,6-difluorobenzoyl)-N'-[4-(alpha-cyclopropyl-4-chlorobenzyloxy)phenyl]urea

Participants

Reaction Steps

1,57 g of 2,6-difluorobenzoylisocyanate was added to a solution of 3,35 g 4-(α-cyclopropyl-4-chlorobenzyloxy)aniline in 30 ml of dry acetonitrile while stirring. After stirring for 1 hour at room temperature the formed precipitate was sucked off, washed with acetonitrile, and dried. The desired product was obtained in a yield of 2.90 g; melting point 185°-188° C. The structure was confirmed by means of CMR.

Provenance & Evidence