HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1285565Generated: October 26, 2026
Epichlorohydrin → 2-Methyl-4-(2,3-epoxypropoxy)benzaldehyde
https://huagongshe.com/reaction/1285565
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Epichlorohydrin | HCID 7835 | — |
| Reactant | 4-Hydroxy-2-methylbenzaldehyde | HCID 458185 | — |
| Reactant | 2-Methyl-4-(2,3-epoxypropyl)benzaldehyde | HCID 20029917 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 2-Methyl-4-(2,3-epoxypropoxy)benzaldehyde | HCID 13302065 | — |
Reaction Steps
To epichlorohydrin (20 g., 0.216 mole) heated at 55° C. is added dropwise a solution of 2-methyl-4-hydroxybenzaldehyde (9.0 g., 0.066 mole) in 2.5N sodium hydroxide solution (40 ml.). After the addition, the solution is allowed to stir an additional 3 hours at 55° C. and then at room temperature overnight. The oil is distilled to give 8.3 g. of 2-methyl-4-(2,3-epoxypropyl)benzaldehyde, m.p. 160°-170° C. at 1 mm. Hg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04567276 |
|---|
| Source dataset | uspto-grants-1986_01 |
|---|
| ORD ID | ord-eea1f61288af42f5941066a1d59c58fe |
|---|
| Source note | uspto-grants-1986_01 |
|---|
