Epichlorohydrin → HCID 20029869, compound

HRID 1285573Notes

Reaction equation

HRID 1285573 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([OH:10])[CH:7]=[C:6]([Cl:11])[C:3]=1[CH:4]=[O:5].[CH2:12]([CH:14]1[O:16][CH2:15]1)Cl>[OH-].[Na+]>[Cl:1][C:2]1[CH:9]=[C:8]([O:10][CH2:12][CH:14]2[O:16][CH2:15]2)[CH:7]=[C:6]([Cl:11])[C:3]=1[CH:4]=[O:5]

Participants

4

Reactant 2

HCID 7835EpichlorohydrinHCID 5283822,6-Dichloro-4-hydroxybenzaldehyde

Product 1

HCID 20029869HCID 20029869, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

To a stirred solution of 2,6-dichloro-4-hydroxy benzaldehyde (3.0 gm 0.0167 m) in 1.5N sodium hydroxide (25 m) at 50° is added epichlorohydrin (4.4 gm, 0.048 m). After stirring at 50° for 3 hours, the solution is cooled and extracted with chloroform. The chloroform is dried over anhydrous sodium sulfate, filtered and concentrated to 2,6-dichloro-4-(2,3-epoxypropoxy)-benzaldehyde (3 g) which is used without further purification.

Workup

  1. temperaturethe solution is cooled
  2. extractionextracted with chloroform
  3. dry with materialThe chloroform is dried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated to 2,6-dichloro-4-(2,3-epoxypropoxy)-benzaldehyde (3 g) which
  6. customis used without further purification

Sources & evidence

ORD record
ord-939dec125f3643cdb8129121a82d587d
Source dataset
uspto-grants-1986_01
Patent number
US04567276

Reaction notes

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