HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-methoxy-4-(1-Boc-4-piperidyloxy)benzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-((1-(Tert-butoxycarbonyl)piperidin-4-YL)oxy)-2-methoxybenzoic acid | HCID 10545874 | — |
| Catalyst | Pyridine | HCID 1049 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-methoxy-4-(1-Boc-4-piperidyloxy)benzoyl chloride | HCID 18914155 | — |
Reaction Steps
2-Methoxy-4-(1-Boc-4-piperidyloxy)benzoic acid (3.2 g, 9.1 mmol) was dissolved in THF (35 ml). Thionyl chloride (1 ml, 1.63 g, 13.7 mmol) was added dropwise, followed by 2 drops of pyridine. The mixture was stirred at ambient temperature under nitrogen for 4.5 hours, then concentrated in vacuo. The residue was reconcentrated from ether to give 2-methoxy-4-(1-Boc-4-piperidyloxy)benzoyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05464788 |
| Source dataset | uspto-grants-1995_11 |
| ORD ID | ord-d9da396479ca493d98c201b4fcb0b532 |
| Source note | uspto-grants-1995_11 |