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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1285988Generated: November 3, 2026

Benzenesulfonamide → Biphenyl

https://huagongshe.com/reaction/1285988

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzenesulfonamideHCID 7370—
Reactant3-BromopyridineHCID 12286—
Reagenttert-Butylimino-tri(pyrrolidino)phosphoraneHCID 3856267—
ReagentHCID 178505364HCID 178505364—
SolventDimethyl SulfoxideHCID 679—
ProductBiphenylHCID 7095—
ProductBenzenesulfonamideHCID 7370—
Product3-BromopyridineHCID 12286—
ProductN-3-PyridylbenzenesulfonamideHCID 339079—

Reaction Steps

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Provenance & Evidence

DOI10.1126/science.1259203
Source datasetHTE Pd-catalyzed cross-coupling screen
ORD IDord-9cd8591731b04e00ad035921af0fcb76
Source noteHTE Pd-catalyzed cross-coupling screen