HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 128605Generated: October 26, 2026
Diethyl (ethoxymethylene)malonate → Diethyl 2-(6-trifluoromethyl-2-pyridylaminomethylene)malonate
https://huagongshe.com/reaction/128605
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| Reactant | 2-Amino-6-(trifluoromethyl)pyridine | HCID 821024 | — |
| Product | Diethyl 2-(6-trifluoromethyl-2-pyridylaminomethylene)malonate | HCID 19374312 | — |
Reaction Steps
A mixture of 6-trifluoromethylpyridin-2-amine (17.2 g) and diethyl ethoxymethylenemalonate (22.9 g) was heated at 95° C., under vacuum for 8 hours. The mixture was cooled and diluted with petroleum ether b.p. 60°-80° C. (50 ml). The mixture was filtered and the residue was recrystallised from IMS to give diethyl 2-(6-trifluoromethyl-2-pyridylaminomethylene)malonate, m.p. 125°-128° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05464781 |
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| Source dataset | uspto-grants-1995_11 |
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| ORD ID | ord-2745d60f2e3c4211bec208894ff000c1 |
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| Source note | uspto-grants-1995_11 |
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