反应详情

A mixture of ethyl butyrylacetate (105.1 g), acetic anhydride (126 ml) and triethylorthoformate (117 ml) was stirred and boiled under reflux for 1.5 hours. The low boiling materials were distilled off under reduced pressure and the residue distilled under high vacuum to give ethyl 2-(ethoxymethylene)-3-oxohexanoate, b.p. 109°-120° C. (0.4 mmHg).

1. temperatureunder reflux for 1.5 hours
2. distillationThe low boiling materials were distilled off under reduced pressure
3. distillationthe residue distilled under high vacuum