HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 128609Generated: October 30, 2026
Diethyl (ethoxymethylene)malonate → Diethyl (6-ethoxy-2-pyridylamino)methylenemalonate
https://huagongshe.com/reaction/128609
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| Reactant | 6-Ethoxy-2-pyridinamine | HCID 586710 | — |
| Product | Diethyl (6-ethoxy-2-pyridylamino)methylenemalonate | HCID 86749097 | — |
Reaction Steps
A mixture of 6-ethoxypyridin-2-amine (8.0 g) and diethyl ethoxymethylenemalonate (12.5 g) was heated at 95° C. under vacuum for 3 hours and then heated at 95° C. at atmospheric pressure for 18 hours. The mixture was cooled to ambient temperature, diluted with petroleum ether b.p. 40°-60° C. and filtered to give diethyl (6-ethoxy-2-pyridylamino)methylenemalonate, m.p. 58°-60° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05464781 |
|---|
| Source dataset | uspto-grants-1995_11 |
|---|
| ORD ID | ord-6ba1fa986b1a415ca28e0a6d84dcfd3e |
|---|
| Source note | uspto-grants-1995_11 |
|---|
