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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1286166Generated: October 30, 2026

3-Bromopyridine → Biphenyl

https://huagongshe.com/reaction/1286166

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-BromopyridineHCID 12286—
ReactantBenzeneethanimidamideHCID 27787—
Reagent2-tert-Butyl-1,1,3,3-tetramethylguanidineHCID 3571581—
ReagentHCID 178454865HCID 178454865—
SolventDimethyl SulfoxideHCID 679—
ProductBiphenylHCID 7095—
Product3-BromopyridineHCID 12286—
ProductBenzeneethanimidamideHCID 27787—
ProductHCID 178510790HCID 178510790—

Reaction Steps

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Provenance & Evidence

DOI10.1126/science.1259203
Source datasetHTE Pd-catalyzed cross-coupling screen
ORD IDord-5843441678624719a7e19c2d75676fc0
Source noteHTE Pd-catalyzed cross-coupling screen