HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 128618Generated: October 31, 2026
Phosphorus oxychloride → 3-Bromo-5-chloro-2-methyl-1,8-naphthyridine
https://huagongshe.com/reaction/128618
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 178432386 | HCID 178432386 | — |
| Product | 3-Bromo-5-chloro-2-methyl-1,8-naphthyridine | HCID 19374303 | — |
Reaction Steps
In a similar manner to Example B1, a mixture of 6-bromo-7-methyl-1,8-naphthyridin-4-ol (3.7 g) and phosphorus oxychloride (25 ml) was stirred at 95° C. for 1 hour to give 3-bromo-5-chloro-2-methyl-1,8-naphthyridine, m.p. 160°-164° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05464781 |
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| Source dataset | uspto-grants-1995_11 |
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| ORD ID | ord-5de5e0a9f6f6485d8d9a11ef297541e6 |
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| Source note | uspto-grants-1995_11 |
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