HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Aminophenoxy)benzene → Ethyl 6-ethoxy-7-methyl-4-(4-phenoxyanilino)-1,8-naphthyridine-3-carboxylate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Aminophenoxy)benzene | HCID 8764 | — |
| Reactant | Ethyl 4-chloro-6-ethoxy-7-methyl-1,8-naphthyridine-3-carboxylate | HCID 23198600 | — |
| Product | Ethyl 6-ethoxy-7-methyl-4-(4-phenoxyanilino)-1,8-naphthyridine-3-carboxylate hydrochloride | HCID 19374343 | — |
Reaction Steps
In a similar manner to Example 1, a mixture of ethyl 4-chloro-6-ethoxy-7-methyl-1,8-naphthyridine-3-carboxylate (1.93 g) and 4-phenoxyaniline (1.33 g) in IMS (40 ml) was boiled under reflux for 2 hours to give ethyl 6-ethoxy-7-methyl-4-(4-phenoxyanilino)-1,8-naphthyridine-3-carboxylate hydrochloride, m.p. 213°-215° C. Active (1/2) at 30 mg/kg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05464781 |
| Source dataset | uspto-grants-1995_11 |
| ORD ID | ord-2361c4e8dc7c4f53bb0660c52271b342 |
| Source note | uspto-grants-1995_11 |