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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1286339Generated: November 1, 2026

1H-Indazole → Biphenyl

https://huagongshe.com/reaction/1286339

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1H-IndazoleHCID 9221—
Reactant3-BromopyridineHCID 12286—
Reagent7-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-eneHCID 123583—
ReagentHCID 178454868HCID 178454868—
SolventDimethyl SulfoxideHCID 679—
ProductBiphenylHCID 7095—
Product1H-IndazoleHCID 9221—
Product3-BromopyridineHCID 12286—
Product1H-Indazole, 1-(3-pyridinyl)-HCID 11356035—

Reaction Steps

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Provenance & Evidence

DOI10.1126/science.1259203
Source datasetHTE Pd-catalyzed cross-coupling screen
ORD IDord-f7bc38ee54cc4ba69be1a6cad515d157
Source noteHTE Pd-catalyzed cross-coupling screen