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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1286344Generated: November 3, 2026

1H-Indazole → Biphenyl

https://huagongshe.com/reaction/1286344

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1H-IndazoleHCID 9221—
Reactant3-BromopyridineHCID 12286—
Reagent1,8-Diazabicyclo(5.4.0)undec-7-eneHCID 81184—
ReagentHCID 178439017HCID 178439017—
SolventDimethyl SulfoxideHCID 679—
ProductBiphenylHCID 7095—
Product1H-IndazoleHCID 9221—
Product3-BromopyridineHCID 12286—
Product1H-Indazole, 1-(3-pyridinyl)-HCID 11356035—

Reaction Steps

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Provenance & Evidence

DOI10.1126/science.1259203
Source datasetHTE Pd-catalyzed cross-coupling screen
ORD IDord-2704770778f84b1bb9c80e8ff1b87e7a
Source noteHTE Pd-catalyzed cross-coupling screen