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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1286366Generated: October 29, 2026

1H-Indazole → Biphenyl

https://huagongshe.com/reaction/1286366

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1H-IndazoleHCID 9221—
Reactant3-BromopyridineHCID 12286—
Reagenttert-Butylimino-tri(pyrrolidino)phosphoraneHCID 3856267—
ReagentHCID 178437371HCID 178437371—
SolventDimethyl SulfoxideHCID 679—
ProductBiphenylHCID 7095—
Product1H-IndazoleHCID 9221—
Product3-BromopyridineHCID 12286—
Product1H-Indazole, 1-(3-pyridinyl)-HCID 11356035—

Reaction Steps

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Provenance & Evidence

DOI10.1126/science.1259203
Source datasetHTE Pd-catalyzed cross-coupling screen
ORD IDord-ec32158126084a3ca3154409fbb8a157
Source noteHTE Pd-catalyzed cross-coupling screen