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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1286521Generated: October 28, 2026

Phenol → Phenol

https://huagongshe.com/reaction/1286521

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhenolHCID 996—
Reactant3-BromopyridineHCID 12286—
Reagent2-((1,1-Dimethylethyl)imino)-N,N-diethylhexahydro-1,3-dimethyl-2lambda5-1,3,2-diazaphosphorin-2-amineHCID 3513851—
ReagentHCID 178454887HCID 178454887—
SolventDimethyl SulfoxideHCID 679—
ProductPhenolHCID 996—
ProductBiphenylHCID 7095—
Product3-BromopyridineHCID 12286—
Product3-PhenoxypyridineHCID 200510—

Reaction Steps

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Provenance & Evidence

DOI10.1126/science.1259203
Source datasetHTE Pd-catalyzed cross-coupling screen
ORD IDord-b15c4d16de3844639a2bf55a9b9eaa52
Source noteHTE Pd-catalyzed cross-coupling screen