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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1286540Generated: October 29, 2026

Phenol → Phenol

https://huagongshe.com/reaction/1286540

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhenolHCID 996—
Reactant3-BromopyridineHCID 12286—
Reagenttert-Butylimino-tri(pyrrolidino)phosphoraneHCID 3856267—
ReagentHCID 178439017HCID 178439017—
SolventDimethyl SulfoxideHCID 679—
ProductPhenolHCID 996—
ProductBiphenylHCID 7095—
Product3-BromopyridineHCID 12286—
Product3-PhenoxypyridineHCID 200510—

Reaction Steps

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Provenance & Evidence

DOI10.1126/science.1259203
Source datasetHTE Pd-catalyzed cross-coupling screen
ORD IDord-499e7f6707904db9b7f2823f8d371c0c
Source noteHTE Pd-catalyzed cross-coupling screen