Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1286556Generated: October 31, 2026

Phenol → Phenol

https://huagongshe.com/reaction/1286556

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhenolHCID 996—
Reactant3-BromopyridineHCID 12286—
Reagent2-tert-Butyl-1,1,3,3-tetramethylguanidineHCID 3571581—
ReagentHCID 178437371HCID 178437371—
SolventDimethyl SulfoxideHCID 679—
ProductPhenolHCID 996—
ProductBiphenylHCID 7095—
Product3-BromopyridineHCID 12286—
Product3-PhenoxypyridineHCID 200510—

Reaction Steps

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Provenance & Evidence

DOI10.1126/science.1259203
Source datasetHTE Pd-catalyzed cross-coupling screen
ORD IDord-59cac8276fb943abbf4e2cfc1fc645d0
Source noteHTE Pd-catalyzed cross-coupling screen