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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1286676Generated: October 28, 2026

Thiophenol → Biphenyl

https://huagongshe.com/reaction/1286676

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThiophenolHCID 7969—
Reactant3-BromopyridineHCID 12286—
Reagent2-tert-Butyl-1,1,3,3-tetramethylguanidineHCID 3571581—
ReagentHCID 178492619HCID 178492619—
SolventDimethyl SulfoxideHCID 679—
ProductBiphenylHCID 7095—
ProductThiophenolHCID 7969—
Product3-BromopyridineHCID 12286—
Product3-PHENYLTHIOPYRIDINEHCID 3813610—

Reaction Steps

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Provenance & Evidence

DOI10.1126/science.1259203
Source datasetHTE Pd-catalyzed cross-coupling screen
ORD IDord-12f15fa0b4a6408a8380d58f8a64315f
Source noteHTE Pd-catalyzed cross-coupling screen