Hydrazine → alpha,alpha-Difluoro-beta-hydroxy-3-(4-pyridinyl)-propanoic acid, hydrazide

Participants

Reaction Steps

α,α-difluoro-β-hydroxy-3-(4-pyridinyl)-propanoic acid, hydrazide (50) was prepared in the manner described in Example 10 on a 20 mmol scale using ethyl α,α-difluoro-β-hydroxy-3-(4-pyridinyl)-propanoate and hydrazine to yield 2.7 g (62%) of product. This product was used immediately in the manner described in Example 51, below.

Provenance & Evidence