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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1286708Generated: October 28, 2026

3-Bromopyridine → Biphenyl

https://huagongshe.com/reaction/1286708

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-BromopyridineHCID 12286—
ReactantDiphenylphosphineHCID 70017—
Reagenttert-Butylimino-tri(pyrrolidino)phosphoraneHCID 3856267—
ReagentHCID 178421999HCID 178421999—
SolventDimethyl SulfoxideHCID 679—
ProductBiphenylHCID 7095—
Product3-BromopyridineHCID 12286—
ProductDiphenylphosphineHCID 70017—
ProductHCID 11334531HCID 11334531—

Reaction Steps

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Provenance & Evidence

DOI10.1126/science.1259203
Source datasetHTE Pd-catalyzed cross-coupling screen
ORD IDord-c56d8f78979247e98a6a24702ccb53fc
Source noteHTE Pd-catalyzed cross-coupling screen