5-(Pyridin-2-yl)thiophene-2-carboxylic acid → HCID 86748371, 화합물

HRID 128676노트

반응식

HRID 128676 반응식
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[O:6][C:7]3[CH:18]=[CH:17][CH:16]=[CH:15][C:8]=3[CH2:9][N:10]([C:11]([NH:13][NH2:14])=[O:12])[C:4]=2[CH:3]=1.[N:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[C:27]1[S:31][C:30]([C:32](O)=[O:33])=[CH:29][CH:28]=1>>[N:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[C:27]1[S:31][C:30]([C:32]([NH:14][NH:13][C:11]([N:10]2[CH2:9][C:8]3[CH:15]=[CH:16][CH:17]=[CH:18][C:7]=3[O:6][C:5]3[CH:19]=[CH:20][C:2]([Cl:1])=[CH:3][C:4]2=3)=[O:12])=[O:33])=[CH:29][CH:28]=1

참가 물질

3

반응물 2

HCID 7364825-(Pyridin-2-yl)thiophene-2-carboxylic acidHCID 135604618-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, hydrazide

생성물 1

HCID 86748371HCID 86748371, 화합물

실험 절차

8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[5-(2-pyridyl)thienylcarbonyl]hydrazide (62) was prepared in the manner described in Example 7 on a 10 mmol scale from 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, hydrazide (1), prepared as described above in Example 1, and 5-(2-pyridyl)thiophene-2-carboxylic acid. The yield of product was 1.33 g (28%). Analysis calculated for C24H17N4O3SCl (M.W. 476.95): C, 60.44; H, 3.59; N, 11.75; Cl, 7.43; S, 6.72. Found: C, 60.18; H, 3.66; N, 11.69; Cl, 7.79; S, 6.63.

후처리

  1. customprepared

출처 및 근거

ORD 기록
ord-f43cc15c5d99490bba418965dc092221
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05464830

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