Acetic Acid → HCID 57166148, compound

Participants

Reaction Steps

A mixture of ethyl 4-chloro-3-oxo-butanoate (57.3 ml) , cyclohexylaldehyde (53.65 ml ) , acetic acid (2.75 ml) and benzylamine (4.38 ml) is kept for 24 hours at room temperature, then it is diluted with 150 ml of AcOEt and washed with 100 ml of water, then with a NaH2PO4 saturated solution. Solvent is evaporated off to obtain 108.43 g of 4-chloro-3-oxo-2-ethoxycarbonyl-1-cyclohexylbut-1-ene.

Provenance & Evidence