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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1286828Generated: October 31, 2026

Water → Biphenyl

https://huagongshe.com/reaction/1286828

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
Reactant3-BromopyridineHCID 12286—
Reactant1-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleHCID 2734771—
Reagenttert-Butylimino-tri(pyrrolidino)phosphoraneHCID 3856267—
ReagentHCID 178439017HCID 178439017—
SolventDimethyl SulfoxideHCID 679—
ProductBiphenylHCID 7095—
Product3-BromopyridineHCID 12286—
Product1-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleHCID 2734771—
ProductHCID 42628230HCID 42628230—

Reaction Steps

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Provenance & Evidence

DOI10.1126/science.1259203
Source datasetHTE Pd-catalyzed cross-coupling screen
ORD IDord-5e84b19443724e61874f7b27e94299ac
Source noteHTE Pd-catalyzed cross-coupling screen