Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1286855Generated: November 1, 2026

Water → Biphenyl

https://huagongshe.com/reaction/1286855

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
Reactant3-BromopyridineHCID 12286—
Reactant1-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleHCID 2734771—
Reagent7-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-eneHCID 123583—
ReagentHCID 178492615HCID 178492615—
SolventDimethyl SulfoxideHCID 679—
ProductBiphenylHCID 7095—
Product3-BromopyridineHCID 12286—
Product1-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleHCID 2734771—
ProductHCID 42628230HCID 42628230—

Reaction Steps

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Provenance & Evidence

DOI10.1126/science.1259203
Source datasetHTE Pd-catalyzed cross-coupling screen
ORD IDord-2c87c2e36171446db76b6ae57b79df47
Source noteHTE Pd-catalyzed cross-coupling screen