Acetone → HCID 19374858, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve under argon 2.9 g of potassium thiocyanate in 30 mol of acetone in a 100-ml three-necked flask. Cool to 0° C. and add 3.4 ml of pivaloyl chloride dropwise. Stir at 0° C. for 5 hours and then add 4.8 g of N-(cyclopropylmethyl)-1-(4-pyridyl)ethylamine (Compound 61). Stir at room temperature overnight. Evaporate to dryness. The residue is taken up in water and extracted into methylene chloride. Dry over anhydrous sodium sulphate and evaporate to dryness. The powder obtained is washed with hexane and filtered off.

Provenance & Evidence