HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 4-(2,4-dichlorophenyl)-5-methyl-2-[N-(alpha-methylbenzyl)-N-(cyclopropylmethyl)amino]thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Bromo-1-(2,4-dichlorophenyl)propan-1-one | HCID 10923991 | — |
| Reactant | 4-(2,4-dichlorophenyl)-5-methyl-2-[N-(alpha-methylbenzyl)amino]thiazole | HCID 19374863 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Bromomethylcyclopropane | HCID 81503 | — |
| Product | 4-(2,4-dichlorophenyl)-5-methyl-2-[N-(alpha-methylbenzyl)-N-(cyclopropylmethyl)amino]thiazole | HCID 19374850 | — |
Reaction Steps
At 0° C., add 0.5 g of 4-(2,4-dichlorophenyl)-5-methyl-2-[N-(α-methylbenzyl)amino]thiazole (prepared from Compound 92 and Compound 15 according to the process described in Example 1), dissolved in 5 ml of anhydrous tetrahydrofuran, and 66 mg of sodium hydride. After 30 minutes of stirring at room temperature, run in 0.67 ml of cyclopropylmethyl bromide dropwise. Leave for eight hours under reflux, cool and dilute the reaction medium with methylene chloride, then pour it onto ice.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05464847 |
| Source dataset | uspto-grants-1995_11 |
| ORD ID | ord-3582406116dd456cb4435c34ea56e06e |
| Source note | uspto-grants-1995_11 |