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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1286975Generated: October 31, 2026

Diethyl Malonate → Biphenyl

https://huagongshe.com/reaction/1286975

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethyl MalonateHCID 7761—
Reactant3-BromopyridineHCID 12286—
Reagent7-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-eneHCID 123583—
ReagentHCID 178492611HCID 178492611—
SolventDimethyl SulfoxideHCID 679—
ProductBiphenylHCID 7095—
ProductDiethyl MalonateHCID 7761—
Product3-BromopyridineHCID 12286—
ProductHCID 11310925HCID 11310925—

Reaction Steps

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Provenance & Evidence

DOI10.1126/science.1259203
Source datasetHTE Pd-catalyzed cross-coupling screen
ORD IDord-d88222d9e7c44c2a9142e852ed5454dd
Source noteHTE Pd-catalyzed cross-coupling screen