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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1287118Generated: November 2, 2026

3-Bromopyridine → Biphenyl

https://huagongshe.com/reaction/1287118

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-BromopyridineHCID 12286—
Reactant1-Butyl-4-ethynylbenzeneHCID 2775132—
Reagent1,8-Diazabicyclo(5.4.0)undec-7-eneHCID 81184—
ReagentHCID 178458463HCID 178458463—
SolventDimethyl SulfoxideHCID 679—
ProductBiphenylHCID 7095—
Product3-BromopyridineHCID 12286—
Product1-Butyl-4-ethynylbenzeneHCID 2775132—
ProductHCID 178440834HCID 178440834—

Reaction Steps

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Provenance & Evidence

DOI10.1126/science.1259203
Source datasetHTE Pd-catalyzed cross-coupling screen
ORD IDord-ec3c41798c1c4865b65fb9414e3eb534
Source noteHTE Pd-catalyzed cross-coupling screen