HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 2-Benzylamino-5,8-dimethoxy-3,4-dihydronaphthalene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | 5,8-Dimethoxy-2-tetralone | HCID 99595 | — |
| Solvent | Toluene water | HCID 22272177 | — |
| Product | 2-Benzylamino-5,8-dimethoxy-3,4-dihydronaphthalene | HCID 9994662 | — |
Reaction Steps
A mixture containing 82 mmol of 5,8-dimethoxy-3,4-dihydronaphthalen-2(1H)-one, 82 mmol of benzylamine and 0.20 g of p-toluenesulfonic acid is brought to reflux with azeotropic distillation of the water/toluene mixture. After heating for 2 hours, the mixture is cooled, filtered and the solvent evaporated under vacuum and leads to the expected product in the form of an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05464859 |
| Source dataset | uspto-grants-1995_11 |
| ORD ID | ord-ce4f4af2d02648e4ab62477824c8d3f9 |
| Source note | uspto-grants-1995_11 |