Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1287129Generated: October 30, 2026

3-Bromopyridine → Biphenyl

https://huagongshe.com/reaction/1287129

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-BromopyridineHCID 12286—
Reactant1-Butyl-4-ethynylbenzeneHCID 2775132—
Reagent2,N'3,N'3,N3,N3,N'5,N'5,N5,N5-nonamethyl-2,4,6-triaza-3lambda5,5lambda5-diphosphaocta-3,5-diene-3,3,5,5-tetramineHCID 3393106—
ReagentHCID 178454865HCID 178454865—
SolventDimethyl SulfoxideHCID 679—
ProductBiphenylHCID 7095—
Product3-BromopyridineHCID 12286—
Product1-Butyl-4-ethynylbenzeneHCID 2775132—
ProductHCID 178440834HCID 178440834—

Reaction Steps

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Provenance & Evidence

DOI10.1126/science.1259203
Source datasetHTE Pd-catalyzed cross-coupling screen
ORD IDord-aac3cd57ced74f1c9407dc205755fa5b
Source noteHTE Pd-catalyzed cross-coupling screen