HRID128718

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID74192

(1,1'-Biphenyl)-4-sulphonyl chloride

C12H9ClO2S

HCID15453191

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCc1c(C(F)(F)F)noc1NS(=O)(=O)c1ccc(-c2ccccc2)cc1

HCID15453192

未命名化合物

收率 81%

PROCEDURE

实验过程

N-(4-Tridecyl-3-trifluoromethyl-5-isoxazolyl)-4-biphenylsulfonamide was prepared, in the same manner as described in Example 2b, from 5-amino-4-tridecyl-3-trifluoromethyl-isoxazole and 4-biphenylsulfonyl chloride in 81% yield. Purification was achieved by recrystallization from methanol/water to give an off white solid, m.p. 115°-116° C.

WORKUP

后处理

customPurification
customwas achieved by recrystallization from methanol/water
customto give an off white solid, m.p. 115°-116° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-58e39f9627cb4cddba8390d650a1854b
来源数据集: uspto-grants-1995_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05464853
来源说明: uspto-grants-1995_11

反应 SMILES

[NH2:1][C:2]1[O:6][N:5]=[C:4]([C:7]([F:10])([F:9])[F:8])[C:3]=1[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23].[C:24]1([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH:29]=[CH:28][C:27]([S:30](Cl)(=[O:32])=[O:31])=[CH:26][CH:25]=1>>[CH2:11]([C:3]1[C:4]([C:7]([F:10])([F:9])[F:8])=[N:5][O:6][C:2]=1[NH:1][S:30]([C:27]1[CH:26]=[CH:25][C:24]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)=[CH:29][CH:28]=1)(=[O:32])=[O:31])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]