HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1,1'-Biphenyl)-4-sulphonyl chloride → N-(4-bromo-5-methyl-3-isoxazolyl)-4-biphenylsulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1,1'-Biphenyl)-4-sulphonyl chloride | HCID 74192 | — |
| Reactant | 4-Bromo-5-methyl-1,2-oxazol-3-amine | HCID 2774464 | — |
| Product | N-(4-bromo-5-methyl-3-isoxazolyl)-4-biphenylsulfonamide | HCID 15453175 | 5% |
Reaction Steps
N-(4-bromo-5-methyl-3-isoxazolyl)-4-biphenylsulfonamide was prepared, using the method in Example 1 b, from 3-amino-4-bromo-5-methylisoxazole and 4-biphenylsulfonyl chloride in 5% yield. The product (m.p. 154°-156° C.) was isolated in 51% yield by column chromatography, after recrystallization from ethyl acetate/hexanes. N-(4-Biphenylsulfonyl)-No(4-bromo-5-methyl-3-isoxazolyl)-4-biphenylsulfonamide was obtained in 51% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05464853 |
| Source dataset | uspto-grants-1995_11 |
| ORD ID | ord-07f9636ed4bc404cb5fdb496e88c19bf |
| Source note | uspto-grants-1995_11 |