HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 1-(5-O-Benzoyl-β-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-(2,3,5-tri-O-benzoyl-beta-D-ribofuranosyl)-1,2,4-triazole-3-carboxylic acid methyl ester | HCID 13456804 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(5-O-Benzoyl-β-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide | HCID 22792964 | — |
Reaction Steps
A mixture of 1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxylic acid methyl ester and methanol saturated at 0° with anhydrous ammonia was stirred at 0° for 4 hr. The resulting solution was evaporated to dryness under reduced pressure and the product was crystallized from aqueous ethanol to give 1-(5-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide with mp 182°-184°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03984396 |
| Source dataset | uspto-grants-1976_10 |
| ORD ID | ord-9b9081c3a14b4ab9a2e98bc88ee67ca7 |
| Source note | uspto-grants-1976_10 |