Hydrochloric Acid → HCID 22749253, compound

Participants

Reaction Steps

5 g. of N-carbethoxy acetyl N-methyl 4-methoxy 2-nitro aniline are dissolved in 50 cc. of hot ethanol. After cooling, 15 cc. of water and 3 cc. of a 2% solution of palladium chloride are added. Then 5 cc. of a 20% aqueous solution of sodium borohydride are introduced, while cooling. This is agitated for thirty minutes, without allowing the temperature to exceed 40° C. Then, the excess of reagent is decomposed by acidifying to pH = 2 with hydrochloric acid. After cessation of the gaseous emission, the medium is filtered then neutralised with addition of ammonium hydroxide, N-carbethoxy acetyl N-methyl 4-methoxy o-phenylene diamine precipitates. The precipitate is filtered, washed with water, filtered with suction and dried. Thus, there are obtained 3.75 g of N-carbethoxy acetyl N-methyl 4-methoxy o-phenylene diamine, which is purified by recrystallization in ethanol.

Provenance & Evidence