HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butyl bromide → 1-phenyl 5-butyl 8-chloro 1,2,4,5-tetrahydro 2,4-dioxo-3H-1,5-benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butyl bromide | HCID 8002 | — |
| Reactant | Desmethylclobazam | HCID 89657 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Product | 1-phenyl 5-butyl 8-chloro 1,2,4,5-tetrahydro 2,4-dioxo-3H-1,5-benzodiazepine | HCID 21487691 | — |
Reaction Steps
In the same manner, by acting butyl bromide in the presence of sodium ethylate, starting from 1-phenyl 8-chloro 1,2,4,5-tetrahydro 2,4 -dioxo 3H-1,5-benzodiazepine, there is obtained 1-phenyl 5-butyl 8-chloro 1,2,4,5-tetrahydro 2,4-dioxo-3H-1,5-benzodiazepine (R1 = H, R2 = Cl, R3 = C4H9, R4 = C6H5) melting at 159°- 161° C., upon recrystallisation in 50% ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03984398 |
| Source dataset | uspto-grants-1976_10 |
| ORD ID | ord-7cfbe99e2b384bbfb9f8907a755e68aa |
| Source note | uspto-grants-1976_10 |